Effect of Hypoxen on bioenergetic processes in mitochondria and ATP-sensitive potassium-channel activity
S. V. Murzaeva, M. B. Abramova, I. I. Popova, E. N. Gritsenko, G. D. Mironova, E. I. Lezhnev · 2010 · Biofizika. 55(5):814–821; English translation Biophysics 55:727–732
What does this source report?
At low experimental concentrations, the authors report increased respiration, coupling, hydrogen-peroxide formation and potassium-associated mitochondrial swelling. ATP-related responses led them to propose involvement of mitochondrial ATP-sensitive potassium channels.
- Population and setting
- Isolated rat heart and liver mitochondria
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian; English abstract
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Concentration, substrate and tissue differ from the respiration-inhibition experiments.
- Increased peroxide formation complicates a simple antioxidant narrative; these assays do not establish clinical benefit.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Journal article
Review depth: Abstract reviewed
Source access and review scope
Indexed or publisher abstract reviewed; full methods and risk of bias not appraised.
Recorded source-check date: 2026-10-04. This date does not imply a completed systematic review.
Cite and trace this record
Original source: S. V. Murzaeva, M. B. Abramova, I. I. Popova, E. N. Gritsenko, G. D. Mironova, E. I. Lezhnev. Effect of Hypoxen on bioenergetic processes in mitochondria and ATP-sensitive potassium-channel activity Biofizika. 55(5):814–821; English translation Biophysics 55:727–732 2010.
Molekul research summary: https://molekul.io/research/hypoxen-katp-2010. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry