HAEE and amyloid-β clearance in mice and cell assays
Mukhina KA, Varshavskaya KB, Rybak AD, Grishchenko VV, Kuzubova EV, Korokin MV, Kechko OI, Mitkevich VA · 2025 · International Journal of Molecular Sciences
Reported findings and study design
The authors measured brain homogenates three days after intracerebroventricular oligomeric amyloid-β injection and a course of HAEE. Figure 1 lists n=8 for the brain measurements.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Brain amyloid-β and IL-6 | 35% lower amyloid-β and 40% lower IL-6 with HAEE. | |
| Brain TNF-α | No change with HAEE. | |
| Microglial amyloid degradation | Approximately 2× the degradation rate in a separate cell experiment. |
This acute experimental challenge and the cell assays address clearance mechanisms. Clinical effects remain unknown.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- This acute experimental challenge and the cell assays address clearance mechanisms. Clinical effects remain unknown.
Source access
Original full text checked for selected methods and findings.
Source reviewed 2026-11-12.
Source type: Journal publication
Citation and original source
Original source: Mukhina KA, Varshavskaya KB, Rybak AD, Grishchenko VV, Kuzubova EV, Korokin MV, Kechko OI, Mitkevich VA. HAEE and amyloid-β clearance in mice and cell assays International Journal of Molecular Sciences 2025.
Molekul research summary: https://molekul.io/research/haee-amyloid-clearance-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry