Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep.
Obál F Jr, Kovalzon VM, Kalikhevich VN, Török A, Alföldi P, Sáry G, Hajós M, Penke B · 1986 · Pharmacology, biochemistry, and behavior 24(4):889-894
What does this source report?
Ordinary DSIP did not increase sleep. D-Trp¹ and D-Tyr¹ analogues promoted sleep, while a shortened D-Trp¹ fragment produced arousal.
- Population and setting
- Rats; intracerebroventricular administration
- Evidence type
- Animal / experimental
- Preparation
- DSIP and modified analogues
- Source language
- eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Structure and experimental timing matter. Central animal administration cannot be transferred to commercial DSIP products.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed metadata and abstract checked via PubMed / Europe PMC; full methods and risk-of-bias assessment pending.
Recorded source-check date: 2026-10-01. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Obál F Jr, Kovalzon VM, Kalikhevich VN, Török A, Alföldi P, Sáry G, Hajós M, Penke B. Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep. Pharmacology, biochemistry, and behavior 24(4):889-894 1986.
Molekul research summary: https://molekul.io/research/dsip-3754970. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry