A sustainable twist on the Ritter reaction: iron-based deep eutectic solvents as a green route to amide synthesis
Luciana Cicco, Arfa Yousaf, Paola Vitale, Filippo Maria Perna, Vito Capriati · 2025 · RSC Sustainability. 2025;3:4079–4086. First published 15 July 2025; CC BY 3.0
Published 2025-07-15.
Study data at a glance
- Participants or experimental model
- Chemical synthesis and analytical characterization; no animal or human pharmacology experiment.
- Reported results
- The publication uses Chlodantane as a gram-scale demonstration of a reusable reaction medium for amide chemistry. It reports an 89% isolated yield for that demonstration and evaluates process sustainability. Its significance is continued chemical-method development and analytical characterization, rather than evidence of clinical effectiveness.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The article labels the example ADK-919, whereas the historical Chlodantane records use ADK-910. That discrepancy is retained and ADK-919 is not adopted as a confirmed synonym. Chemical yield, purity and process reuse are not pharmacological efficacy or human safety outcomes.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Publisher metadata, abstract and selected indexed full-text passages
Source access and review scope
Publisher abstract, metadata and selected indexed full-text passages checked; the complete publisher PDF could not be retrieved in this pass
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Open original source or index record ↗
DOI: 10.1039/D5SU00489F
Citation and original source
Original source: Luciana Cicco, Arfa Yousaf, Paola Vitale, Filippo Maria Perna, Vito Capriati. A sustainable twist on the Ritter reaction: iron-based deep eutectic solvents as a green route to amide synthesis RSC Sustainability. 2025;3:4079–4086. First published 15 July 2025; CC BY 3.0 2025.
Molekul research summary: https://molekul.io/research/chlodantane-synthesis-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry