Efficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial.
Muresanu DF, Florian S, Hömberg V, Matula C, von Steinbüchel N, Vos PE, von Wild K, Birle C, Muresanu I, Slavoaca D, Rosu OV, Strilciuc S, Vester J · 2020 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
What does this source report?
CAPTAIN II reports improvement in a multidimensional outcome at 90 days with adjunctive treatment.
- Population and setting
- 142 enrolled; 139 analyzed after moderate–severe traumatic brain injury
- Evidence type
- Randomized trial
- Preparation
- Porcine brain-derived peptide mixture; equivalence to other hydrolysates is not assumed
- Source language
- Indexed English abstract; original language varies
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Single-center trial; a composite benefit does not establish benefit on every outcome. Secondary CAPTAIN reports reuse this cohort.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Citation and indexed abstract checked. Full methods, funding and risk of bias have not been comprehensively appraised.
Recorded source-check date: 2026-09-30. This date does not imply a completed systematic review.
Source provenance: Journal publication
Cite and trace this record
Original source: Muresanu DF, Florian S, Hömberg V, Matula C, von Steinbüchel N, Vos PE, von Wild K, Birle C, Muresanu I, Slavoaca D, Rosu OV, Strilciuc S, Vester J. Efficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2020.
Molekul research summary: https://molekul.io/research/cbl-31897941. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry