Levocarnitine versus amantadine crossover comparison
Plioplys AV, Plioplys S · 1997 · Neuropsychobiology
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Eight weeks each of oral L-carnitine and amantadine with a two-week washout. The original paper used L-carnitine 1 g three times daily and amantadine 100 mg once daily for one week, then twice daily.
Dose, route and schedule
Eight weeks each of oral L-carnitine and amantadine with a two-week washout. The original paper used L-carnitine 1 g three times daily and amantadine 100 mg once daily for one week, then twice daily.
Protocol source ↗ · Original source
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| L-carnitine | 12 of 18 measured clinical parameters improved significantly after eight weeks. | |
| Amantadine | 15/30 discontinued, and the authors reported no significant clinical improvement among those who completed treatment. |
The trial lacked an inactive control. High amantadine discontinuation and multiple measured parameters limit comparisons.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The trial lacked an inactive control. High amantadine discontinuation and multiple measured parameters limit comparisons.
Source access
Eight weeks each of oral L-carnitine and amantadine with a two-week washout. The original paper used L-carnitine 1 g three times daily and amantadine 100 mg once daily for one week, then twice daily.
Source reviewed 2026-11-12.
Citation and original source
Original source: Plioplys AV, Plioplys S. Levocarnitine versus amantadine crossover comparison Neuropsychobiology 1997.
Molekul research summary: https://molekul.io/research/carnitine-amantadine-cfs-1997. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry