Inhibitory effect of 2-substituted benzimidazoles on lymphocyte mitogenesis is associated with AhR-dependent mechanisms

E. S. Sibiryak, S. V. Sadovnikov, S. V. Sibiryak · 2009 · Medical Immunology. 2009;11(4–5):335. Conference abstract

In vitroRussian source · see review scopeSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

What does this source report?

At the reported Bemitil concentration, the table gives only 3±3% inhibition of mitogenesis. The combination with TCDD differed from the Bliss-model expectation. This supports an experimental interaction question, not a claim that Bemitil strongly suppresses human immunity.

Population and setting: Healthy-donor T cells stimulated with anti-CD3; benzimidazoles and TCDD interaction experiment
Evidence type: In vitro
Preparation: See the original report; formulation details require verification.
Source language: Russian
Title provenance: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

Conference abstract and indexed table excerpt, not a full clinical study.
AhR involvement is a proposed mechanism; direct receptor binding and clinical immunosuppression were not demonstrated.
No MS patients, demyelination outcome or clinical benefit assessment.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Document format: Russian conference abstract; indexed PDF excerpt

Review depth: Indexed abstract and table text reviewed

Source access and review scope

Source text reviewed at the access level stated; no independent verification of patient data.

Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.

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Cite and trace this record

Original source: E. S. Sibiryak, S. V. Sadovnikov, S. V. Sibiryak. Inhibitory effect of 2-substituted benzimidazoles on lymphocyte mitogenesis is associated with AhR-dependent mechanisms Medical Immunology. 2009;11(4–5):335. Conference abstract 2009.

Molekul research summary: https://molekul.io/research/bemitil-tcell-2009. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Bemitil

A benzimidazole-derived actoprotector, also indexed as bemethyl and Metaprot. Research spans patient asthenia, occupational settings, neuromuscular and liver studies, metabolism and preclinical safety; these are research contexts, not established uses.

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