The effect of bemetil on production of DNA antibodies in patients with systemic lupus erythematosus
T. A. Lisitsyna, A. D. Durnev, M. M. Ivanova, A. I. Speranskii, S. B. Seredenin, V. A. Nasonova · 1999 · Experimental and Clinical Pharmacology. 1999;62(5):38–41. PMID 10572751
What does this source report?
The abstract reports reduced anti-DNA antibodies and improvements in SLEDAI-1/ECLAM disease-activity measures in Bemitil-containing treatment groups. Background treatment included prednisolone, with or without cyclophosphamide. Numerical effect sizes are not available in the abstract.
- Population and setting
- 61 people with SLE; four groups of 15, 15, 15 and 16; eight-week comparison
- Evidence type
- Human comparative study
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- SLE is a different disease; these findings do not establish efficacy in MS.
- Allocation and blinding cannot be established from the abstract; concomitant therapy complicates attribution.
- Likely related to the 1997 dissertation and 2000 patent: do not count these as independent replication.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Indexed English abstract
Review depth: Abstract reviewed
Related-report group: lisitsyna-sle-1993-1997. Reports in this group are not assumed to be independent trials.
Source access and review scope
Source text reviewed at the access level stated; no independent verification of patient data.
Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.
Cite and trace this record
Original source: T. A. Lisitsyna, A. D. Durnev, M. M. Ivanova, A. I. Speranskii, S. B. Seredenin, V. A. Nasonova. The effect of bemetil on production of DNA antibodies in patients with systemic lupus erythematosus Experimental and Clinical Pharmacology. 1999;62(5):38–41. PMID 10572751 1999.
Molekul research summary: https://molekul.io/research/bemitil-sle-1999. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry