RESEARCH ATLAS
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COMPOUND RECORD / SOY-PEPTIDE-HYDROLYSATE

Soy peptide hydrolysateГидролизат изолята соевого белка

PerformanceStressRecovery
Source linked
01 / OVERVIEW

About Soy peptide hydrolysate

Names in this research collection

SPIH · Soy protein isolate hydrolysate · 6 kDa soy hydrolysate

A specific enzymatic soy-protein hydrolysate with a broad size distribution and average mass near 6 kDa. Its rat swimming study compares a food-derived mixture with whey and free amino acids.

Research background

A specific enzymatic soy-protein hydrolysate with a broad size distribution and average mass near 6 kDa. Its rat swimming study compares a food-derived mixture with whey and free amino acids.

What the studies found

Animal research · 2026

Who or what was studied30 outbred male Wistar rats initially randomized, 10 per group; hydrolyzed soy, whey protein or amino-acid mixture

Reported finding

Soy hydrolysate group mean swimming time rose from 91 to 404 seconds. The reported +511% averages individual percentage changes; the change calculated from the two group means is about +344%.

Soy hydrolysate · absolute swim time
91 → 404 s (+313 s)Baseline to session 11; group means. Approximate group-mean change: +344%.
Soy hydrolysate · individual relative change
+511% mean individual changeEach animal’s result was divided by its own baseline before averaging. Low baselines can inflate relative changes.
Whey and amino-acid comparators
Whey and soy reached within-group significance at session 7; amino acids at session 11p<0.05 in marked paired comparisonsPaired Wilcoxon comparisons with each group’s own baseline; not evidence that the groups differed at those times.
All reported results & study design →
Methods, dose & source notes

Study of this preparation · Original journal article

Four of 30 animals died or were euthanized during the study. The paper reports an esophageal feeding injury, a stroke during swimming and two unexplained deaths; do not attribute causation to soy. Repeated exercise and changing sample counts complicate comparisons. Significant within-arm tests are not between-arm superiority tests. Whey was used because intact soy could not be delivered in the same mixture; this is not a hydrolyzed-versus-intact-soy comparison.

Soy peptide hydrolysate and loaded swimming in rats ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Compound class
Food-derived peptide mixture
Research collection
Actoprotection & occupational pharmacology · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

No human athlete intervention in this study.

Study methods

Repeated loaded swimming in three initially randomized groups; food preparation and analysis denominators are documented.

Independent replication

Independent replication is not established in the linked sources.

Source access

Original sources and the exact review scope are linked below.

Safety evidence

The linked experiments do not establish a safe human performance regimen.

Open a topic for the evidence assessment.

More findings, background and history
EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Appraise original methods and replication; keep animal and cell findings separate from unestablished human benefit and safety.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗
03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2026 · Soy peptide hydrolysate and loaded swimming in ratsSoy hydrolysate · absolute swim time: 91 → 404 s (+313 s)
2026Animal / experimentalFull text available

Soy peptide hydrolysate and loaded swimming in rats

Soy protein isolate hydrolysate with average mass near 6 kDa; no sequence or tissue identity match to PPK-V. · Original journal article

Format: Publisher full PDF (16 pages), methods, Fig. 1, results and analysis limits · Reviewed: Reported methods, results and evidence limitations

N. Pozdnyakov, M. Molchanov, T. Ponomareva, V. Rykov, A. Lukin, S. Shilov, M. Timchenko, E. Sogorin · Discover Food. 6:79

Soy hydrolysate group mean swimming time rose from 91 to 404 seconds. The reported +511% averages individual percentage changes; the change calculated from the two group means is about +344%.

Findings, study figures and available tables

Reported findings and study design

Soy hydrolysate group mean swimming time rose from 91 to 404 seconds. The reported +511% averages individual percentage changes; the change calculated from the two group means is about +344%.

30 outbred male Wistar rats initially randomized, 10 per group; hydrolyzed soy, whey protein or amino-acid mixture

Dose, route and schedule

10 g/kg of the protein–carbohydrate mixture (10 mL/kg enteral) 30 minutes before each test. Swim load 5% of body mass, water 25±1°C, three times weekly for four weeks. D0 was before feeding; day labels refer to swim-test sessions.

Protocol source ↗ · Publisher full PDF (16 pages), methods, Fig. 1, results and analysis limits

Reported findings and study figures · Publisher full PDF (16 pages), methods, Fig. 1, results and analysis limits; supplementary PDF Table 5 checked
MeasureResultComparison, timing and statistics
Soy hydrolysate · absolute swim time91 → 404 s (+313 s)Baseline to session 11; group means. Approximate group-mean change: +344%.
Soy hydrolysate · individual relative change+511% mean individual changeEach animal’s result was divided by its own baseline before averaging. Low baselines can inflate relative changes.
Whey and amino-acid comparatorsWhey and soy reached within-group significance at session 7; amino acids at session 11Paired Wilcoxon comparisons with each group’s own baseline; not evidence that the groups differed at those times. · p<0.05 in marked paired comparisons
MetabolomicsMore than 50 serum metabolites quantified; 19 proteinogenic amino acidsThe endurance response did not track higher circulating proteinogenic amino acids. NMR sampling was after the swim series, with no simultaneous physical load.
Attrition and safety4 of 30 animals died or were euthanized; daily analysis n variedOne esophageal injury during administration, one stroke during swimming, two unexplained deaths. Individual time points could also be excluded for refusing to swim or vest loss.
Final plotted sampleWhey n=9; soy hydrolysate n=8; amino acids n=8Supplement Table 5, session 11; counts differ from initial randomization.
Supplement Table 5 · counts for the plotted swimming tests
Supplement Table 5 · counts for the plotted swimming tests
SessionWheySoy hydrolysateAmino-acid mixture
1989
2988
3989
4988
5887
6889
7989
8989
9989
10988
11988

Sample sizes for the supplementary relative swim-time plots. Initial allocation was 10 per group; analysis counts vary with losses and exclusions.

The result supports testing what food-derived hydrolysates do in this model. The molecular-mass resemblance to PPK-V is a comparison of size only, not evidence of shared molecules, signaling, or human endurance benefit.

Source for the extracted data ↗ · Checked 2026-11-08

Population / setting
30 outbred male Wistar rats initially randomized, 10 per group; hydrolyzed soy, whey protein or amino-acid mixture
What was checked
Publisher full PDF (16 pages), methods, Fig. 1, results and analysis limits
Limitations & review scope
  • Four of 30 animals died or were euthanized during the study. The paper reports an esophageal feeding injury, a stroke during swimming and two unexplained deaths; do not attribute causation to soy.
  • Repeated exercise and changing sample counts complicate comparisons. Significant within-arm tests are not between-arm superiority tests.
  • Whey was used because intact soy could not be delivered in the same mixture; this is not a hydrolyzed-versus-intact-soy comparison.

Source checked 2026-11-08. See the review scope above for the material assessed.

Read the source ↗

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗