N-Isocaproyl-L-Arginylglycine Hexamethylenediamide, First Low-Molecular-Weight Mimetic of Neurotrophin-4: Design and Neuroprotective Activity.
Gudasheva TA, Sokolenko NI, Kolyasnikova KN, Antipova TA, Zainullina LF, Sergeeva MS, Dorofeev VL · 2026 · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
What does this source report?
GZS-411 activated TrkB and protected cultured cells against oxidative stress, glutamate toxicity and 6-hydroxydopamine. The study does not establish animal or human treatment effects.
- Population and setting
- Mouse HT-22 and human SH-SY5Y cell lines
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language: eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Gudasheva TA, Sokolenko NI, Kolyasnikova KN, Antipova TA, Zainullina LF, Sergeeva MS, Dorofeev VL. N-Isocaproyl-L-Arginylglycine Hexamethylenediamide, First Low-Molecular-Weight Mimetic of Neurotrophin-4: Design and Neuroprotective Activity. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 2026.
Molekul research summary: https://molekul.io/research/rp-42443573. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry