Analgesic Activity of the Low Molecular Weight Neurotrophin-3 Dipeptide Mimetic GTS-301.
Kolik LG, Konstantinopolsky MA, Sazonova NM, Durnev AD, Gudasheva TA · 2025 · Doklady. Biochemistry and biophysics
What does this source report?
GTS-301 increased rat tail-flick pain thresholds by about 20–30%, with a reported effect lasting at least 24 hours in this experiment. This endpoint is distinct from the GTS-302 hot-plate test.
- Population and setting
- Rats; acute experimental pain testing
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language: eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Kolik LG, Konstantinopolsky MA, Sazonova NM, Durnev AD, Gudasheva TA. Analgesic Activity of the Low Molecular Weight Neurotrophin-3 Dipeptide Mimetic GTS-301. Doklady. Biochemistry and biophysics 2025.
Molekul research summary: https://molekul.io/research/rp-39847291. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry