Low-Molecular Neurotrophin-3 Mimetics with Different Patterns of Postreceptor Signaling Activation Attenuate Differentially Morphine Withdrawal in Rats.
Kolik LG, Konstantinipolsky MA, Nikolaev SV, Logvinov IO, Antipova TA, Gudasheva TA · 2024 · Biochemistry. Biokhimiia
What does this source report?
GTS-301 and GTS-302 reduced withdrawal signs in morphine-dependent rats; only GTS-302 reduced withdrawal-associated mechanical allodynia. Cell assays reported different downstream signaling, with AKT/mTOR recruitment for GTS-302. A 2025 erratum is linked separately; quantitative estimates are withheld pending reconciliation.
- Population and setting
- Morphine-dependent rats and HT-22 cells
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language: eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Animal withdrawal models are not evidence for treating opioid dependence in people.
- Erratum PMID 40254407 must be reconciled with the full article before relying on numerical estimates.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Related-report group: nt3-withdrawal-2024. Reports in this group are not assumed to be independent trials.
Source access and review scope
Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Kolik LG, Konstantinipolsky MA, Nikolaev SV, Logvinov IO, Antipova TA, Gudasheva TA. Low-Molecular Neurotrophin-3 Mimetics with Different Patterns of Postreceptor Signaling Activation Attenuate Differentially Morphine Withdrawal in Rats. Biochemistry. Biokhimiia 2024.
Molekul research summary: https://molekul.io/research/rp-39647825. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry