Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115.
Kolik LG, Gudasheva TA, Seredenin SB · 2012 · Bulletin of experimental biology and medicine
What does this source report?
GB-115 countered some CCK-4-induced behavioral responses but not yohimbine-induced anxiety in C57Bl/6 mice, indicating model-dependent effects rather than universal anxiolysis.
- Population and setting
- Rats and BALB/c and C57Bl/6 mice
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language: eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Kolik LG, Gudasheva TA, Seredenin SB. Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115. Bulletin of experimental biology and medicine 2012.
Molekul research summary: https://molekul.io/research/rp-23113301. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry