Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2.

B. Raphael-Mizrahi, M. Attar-Namdar, M. Chourasia, M. G. Cascio, Y. Gabet, et al. · 2022 · eLife. 11:e65834

Animal / experimentalEnglish abstractSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

What does this source report?

The authors reported bone and inflammatory effects that disappeared after genetic or pharmacological disruption of CB2. Circulating OGP declined with age in the women sampled; this was not a treatment trial.

Population and setting: Mouse models, cell assays including human osteoblasts, and observational human serum measurements
Evidence type: Animal / experimental
Preparation: OGP experimental preparations; sequence-specific methods require full-text appraisal
Source language: English
Title provenance: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

Mouse treatment and cultured human cells do not demonstrate human treatment efficacy.
The human serum association cannot establish causation.
Full-length OGP and the active fragment must be distinguished in each experimental method.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Document format: Journal article

Review depth: Indexed abstract reviewed

Source access and review scope

Original publication metadata and indexed abstract checked; full methods and tables not appraised.

Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.7554/eLife.65834

Cite and trace this record

Original source: B. Raphael-Mizrahi, M. Attar-Namdar, M. Chourasia, M. G. Cascio, Y. Gabet, et al.. Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2. eLife. 11:e65834 2022.

Molekul research summary: https://molekul.io/research/gaps-ogp-35604006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Osteogenic growth peptide

An international peptide-research comparator with original osteoblast and rodent studies. Full-length OGP, its active fragment and marrow extracts are distinct research preparations.

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