Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity.
I. Bab, D. Gazit, M. Chorev, A. Muhlrad, A. Shteyer, Z. Greenberg, M. Namdar, A. Kahn · 1992 · EMBO Journal. 11(5):1867–1873
What does this source report?
Synthetic 14-amino-acid OGP increased osteoblast proliferation and alkaline-phosphatase activity in culture and increased bone mass in injected rats.
- Population and setting
- Osteoblast cultures and rats
- Evidence type
- Animal / experimental
- Preparation
- 14-amino-acid OGP; not a marrow extract
- Source language
- English
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Preclinical endpoints do not establish fracture prevention or benefit in people.
- The full-length peptide must be distinguished from its 10–14 fragment and tissue mixtures.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Journal article
Review depth: Indexed abstract reviewed
Source access and review scope
Original publication metadata and indexed abstract checked; full methods and tables not appraised.
Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.
Cite and trace this record
Original source: I. Bab, D. Gazit, M. Chorev, A. Muhlrad, A. Shteyer, Z. Greenberg, M. Namdar, A. Kahn. Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity. EMBO Journal. 11(5):1867–1873 1992.
Molekul research summary: https://molekul.io/research/gaps-ogp-1582415. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry