Dalargin and oxidative stress in severe combined trauma: a prospective clinical study
V. V. Antonova, A. K. Evseev, I. V. Goroncharovskaya, A. Yu. Ryzhkov, O. A. Grebenchikov, A. K. Shabanov · 2023 · Annals of Critical Care. 2023;(4):185–196
What does this source report?
Among 104 patients (38 Dalargin, 66 controls), the authors reported lower oxidative-stress markers and fewer ARDS/acute kidney injury events. Mortality and infectious complications were comparable; antioxidant activity remained below normal. Hospitalization was shorter among survivors receiving Dalargin.
- Population and setting
- 104 severe combined-trauma patients
- Evidence type
- Human comparative study
- Preparation
- See the original report; formulation details require verification.
- Source language
- English abstract or source translation
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Unequal groups; randomized allocation and blinding not established in this appraisal.
- Biomarker changes do not prove improved survival; survivor-only length of stay requires caution.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Selected text reviewed
Source access and review scope
Selected source text and metadata checked; full risk-of-bias review pending.
Recorded source-check date: 2026-10-04. This date does not imply a completed systematic review.
Cite and trace this record
Original source: V. V. Antonova, A. K. Evseev, I. V. Goroncharovskaya, A. Yu. Ryzhkov, O. A. Grebenchikov, A. K. Shabanov. Dalargin and oxidative stress in severe combined trauma: a prospective clinical study Annals of Critical Care. 2023;(4):185–196 2023.
Molekul research summary: https://molekul.io/research/dalargin-trauma-2023. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry