Pharmaceutical grade synthetic peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu ameliorates DSS-induced murine colitis by reducing the number and pro-inflammatory activity of colon tissue-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes.
Chulkina MM, Pichugin AV, Ataullakhanov RI · 2020 · Peptides · PMID 32621844
What does this source report?
Gepon reduced experimental colitis manifestations, inflammatory-cell infiltration and selected inflammatory gene signals.
- Population and setting
- Mice with dextran-sodium-sulphate-induced colitis
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language:
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- A chemically induced mouse model does not establish benefit or safety in human ulcerative colitis.
- Full methods, reporting completeness and independent replication remain to be appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary citation and indexed abstract reviewed through Europe PMC. Full article not appraised.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Source provenance: Original journal report
Cite and trace this record
Original source: Chulkina MM, Pichugin AV, Ataullakhanov RI. Pharmaceutical grade synthetic peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu ameliorates DSS-induced murine colitis by reducing the number and pro-inflammatory activity of colon tissue-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes. Peptides · PMID 32621844 2020.
Molekul research summary: https://molekul.io/research/audit-32621844. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry